Alpha Fat Burners

Advanced Nutrition System Metabolic Sphere Review

A product by Advanced Nutrition System

Overall Rating:


Positives Negatives
  • Contains Caffeine
  • Poor Servings
  • Ineffective Nutrient Profile
  • Potential Side Effects

Review Overview – What does Advanced Nutrition Systems’ Metabolic Sphere do?

This is an all natural fat burner, brought to us by Advanced Nutrition Systems.

Sure, Metabolic Sphere looks great and it’s claimed to promote:

  • Energy
  • Metabolism
  • Thermogenic Fat Burning
  • Focus


But how well does it actually work?

In this review, we take a closer look at Metabolic Sphere and show you how effective it actually is.

This is what you need to know:

How are the servings?


With only 1 serving a day – there’s only so much you benefit that you can get from this fat burner.

You want to stay in fat burning mode for as long as possible – with 1 serving a day you’re only going to get a few hours.

Plus, your body can only absorb so much at a time.

Ideally, what you want is something that provides 3 – 4 servings per day.

This way you’re constantly being supplied with the nutrients you need, and your progress will be a lot faster.

What about the ingredients in Metabolic Sphere?

Not that great.

The majority of this fat burner is a full-on proprietary blend.

That means all the ingredients have been bundled in together. You don’t know how much you’re getting, or how effective it will be.

And there’s also a risk of side effects.

Check it out:metabolic-sphere-side-effects


One of the better vitamins for fat loss.

B12 has been linked to supporting various metabolic reactions in the body.

With this extra supply, there should be a mild boost in your metabolism.


Arguably the best natural stimulant out there.

Caffeine has been linked to promoting energy, metabolism, and if there’s enough power output.

It’ll definitely help towards your gym sessions when working out.


Not a fat burner, but may have some benefit.

One of the main benefits of this herb is its ability to promote calmness and de-stress you.

This could help if you’re sensitive to the caffeine in this product.

Bitter Orange and Synephrine

Not the best choice – in fact one of the worst.

Synephrine is derived from Bitter Orange, and they’re both believed to give the same kind of effect – stimulate and burn fat.

However, studies have shown it isn’t that good at it – in fact, it may even cause side effects, especially when combined with caffeine.

These nutrients are pretty poor, and to some effect dangerous. We’ll cover the side effects in more detail later on.

Huperzine A

Used for mental performance, but not all it’s cracked up to be.

Although it has been seen to improve focus to some extent, studies have shown that you can build up a tolerance to this nutrient pretty quickly.

To get the most benefit you may have to cycle Huperzine A – which is hard when you take this fat burner every day.


An effective appetite suppressant – but it may cause side effects.

You can find out more about the risks of this bark extract in the side effects section later.

Mucuna Pruriens

Also known as Velvet Bean – this nutrient is known for its serotonin and may increase your body’s level of L-Dopa.

Is this a good thing? It’ll help reduce your body’s stress levels. But it won’t necessarily hell with fat loss.

Safflower (CLA)

Used for the Conjugated Linoleic Acid.

CLA is a stimulant-free fat burner. However, it only seems to work in theory.

By manipulated certain receptors in your body, it is thought to increase fat loss.

However, studies have shown that in practice, it does have a strong enough impact to make a difference.

It’s not a great choice.metabolic-sphere-results

Ingredients Bottom Line:

On the whole, Metabolic Sphere doesn’t have the best nutrient profile.

The first problem is the proprietary blend. There’s so many ingredients, and we don’t how much we’re getting with pretty much any of them.

There’s also a handful of ineffective ingredients, and even some that cause side effects.

All in all, it’s just not a great choice.

Side Effects

The main two ingredients you have to worry about here are the Bitter Orange/Synephrine, and the Yohimbine.

The Bitter Orange/Synephrine has been linked to causing side effects when combined with Caffeine or caffeinated herbs.

These include:

  • Headaches
  • Raised Blood Pressure
  • Increased Heart rate
  • Increased Chance of Stroke

Whereas the Yohimbine has been linked to:

  • Anxiety
  • Hypertension
  • Gastrointestinal Distress

A laundry list of side effects, nobody wants while cutting fat.

Is there anything better than this fat burner?


We’ve scoured the market for the best fat burners that promote:

  1. Thermogenic Calorie Burning
  2. Energy Levels
  3. Fat Loss
  4. Appetite Suppression

And we’ve narrowed it down to just three.

To see what works best for men, and what works best for women, check out the top 3 rated fat burners on the market in the links below:

Best Fat Burners for Men
Best Fat Burners for Women

Metabolic Sphere Review Conclusion

On the whole, this isn’t the best fat burner out there – by far.

From this review, this is what you need to know about Metabolic Sphere by Advanced Nutrition Systems:

  • Poor Servings – With only 1 serving per day, you can’t ensure round the clock fat burning.
  • Ineffective ingredients – Many of the nutrients used lack the proper clinical backing for maximum effect.
  • Potential Side Effects – Both Bitter Orange Extract/Synephrine and Yohimbe have been linked to causing side effects.

All in all, it’s not a great choice.

To see what our readers, and our editor, have chosen as their highest rated fat burner – check out our full review of the current #1:

What I'm using at the moment - Instant Knockout

I tried Instant Knockout for 3 months and went from skinny-fat to absolutely SHREDDED.

You can see my results and why this is our #1 Fat Burner here.

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